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J Pharmacol Exp Ther 240(3):883889 Glare P, Miller J, Nikolova T, Tickoo R (2011) Treating nausea and vomiting in palliative care: a review

ATP insufficiency also adversely affects neuronal function by disrupting Ca + regulation, impairing synaptic activity and neurotransmitter synthesis (7880)., and activating the AMPK-mTOR pathway to inhibit protein synthesis and cellular repair (81, 82)

The past 10 years, however, have seen the development of enzyme therapy for arginase deficiency and gene therapy for ornithine transcarbamylase deficiency